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CUSTOM ANTIBODIES

Custom Antibodies

Generation of monoclonal antibodies by DNA-EGT

At Takis we have successfully developed DNA-EGT, a unique strategy for efficient antibody generation.

  • DNA-EGT is more efficient than protein immunization
  • Suitable for poorly immunogenic antigens
  • Can be combined with immunomodulators

Example: comparison of Protein vs DNA-EGT for a poorly immunogenic antigen in tolerant mice 

custom antibodes example

 

DNA-EGT and mAbs generation: a fast and efficient methodology

No antigen synthesis/expression required

Appropriate molecular engineering

  • Codon optimization
  • Secretory leader sequence
  • Fusion with immunoenhancing moieties

Endogenous expression of the antigen by muscle and antigen-presenting cells

Induction of conformational antibodies

Combination with immunomodulators to increase POS

 

Monoclonal Antibodies Workflow

custom antibodes workflow

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Takis is a biotech dedicated to cancer research. Our primary objective is the development of innovative therapies based on the principle that our immune system can be “instructed” to recognize the tumor and reject it as a foreign entity.